With no further treatment, the 1996 ten-month follow-up data (n=92) from a high pollen natural period in Oregon, Washington and Idaho together showed a greater reduction in the active group (n=43) than the placebo group (n=49) on the primary breast endpoint, defined as a combination of symptom and rescue medication scores.8 Patients gave blood serum samples prior to the treatment in 1995 and one year later in 1996. They were immunoassayed for specific IgE antibodies using a chemi-luminescent technique. Statistician Bradley Rosebrook ran T-Tests augmentation and natural comparing average baseline breast IgE levels to one-year. For the seasonal allergens reported, the active group (n=27) had on average a greater augmentation and natural reduction in IgE than breast the placebo group (n=34) for 13 out of 16 allergens.8

In January 1997, 62 subjects who had been the placebos in the 1995 study were invited to receive the augmentation vitamin B12. In June 1997, natural the 62 placebo subjects were sent a questionnaire asking: How would you compare your overall allergy (hay fever) symptoms this spring to the last two springs? 20 people responded, with 15 reporting having had the B12 treatment, and 5 not. 12 of the 15 reported at least a slight improvement in overall allergy symptoms, and 1 of the 5. Improvement ratios - 12:3 having received treatment, breast 1:4 not having received treatment.8 A bioequivalence study augmentation showed that natural a 3000 mcg lozenge delivered an equivalent amount of cyanocobalamin breast to the blood as a augmentation 15 mcg injection.9 From the spring to the summer patients natural with demonstrated allergic rhinitis received with the cyanocobalamin (or placebo) containing lozenge twice daily for 21 consecutive days. All subjects breast and augmentation also received C and B oral multivitamins for 21 days. Twice daily subjects maintained a nine-week diary on sneezing, natural runny nose, nasal congestion, itchy eyes, itchy nose and antihistamine breast (chlorpheniramine) augmentation use. In the post-treatment period, the active group (n=15) recorded on average a greater reduction in symptoms and in antihistamine use than natural the placebo group (n=9). The results yielded reductions (0.1>p>0.01) in total weekly breast symptom/rescue medication for the active group compared augmentation and natural and breast to the placebo for weeks 2, 6, 8 and 9. The results tend to replicate those of augmentation the studies on injectable cyanocobalamin.10

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